How many polynucleotide sessions do I need?

Most people need 2–3 sessions of polynucleotides to achieve healthy, long-lasting skin improvement. At Dermamina, we recommend a 3-session course spaced 3–4 weeks apart, as this supports collagen production, tissue repair and hydration in a gradual, natural way.

Initial Course (Induction Phase)

Polynucleotides work by stimulating your skin’s natural healing and repair process — not by adding instant filler volume. Because regeneration takes time, a course of sessions helps the benefits build steadily.

• 2–3 sessions total (Dermamina recommends 3 for best results)
• Spaced 3–4 weeks apart
• Gradual improvement as collagen, elastin and hydration increase
• Visible brightening and smoothing develops across several weeks

Maintenance Sessions

After completing your initial course, a maintenance session every 6 months helps keep results fresh and long-lasting.

• Top-ups every 6 months
• Frequency varies depending on age, skin health and lifestyle
• Helps preserve improved texture, glow and firmness

Why multiple sessions?

Polynucleotides activate fibroblasts, hydration pathways and tissue repair. Because this is a natural biological process, each session builds on the last. Most clients notice:

• More glow and hydration within a few weeks
• Smoother texture and reduced fine lines over 6–12 weeks
• Stronger, healthier-looking skin across 3–6 months

Next Step

To start your personalised plan, visit the main Polynucleotides Treatment page to book your consultation.