A regenerative injectable that repairs, hydrates and rebuilds skin quality from within. No volume, no filled look, just better skin.
Real patient results from our London clinic. Skin that looks rested and resilient, with the same features you walked in with.
Areas shown include full face and under-eye · Rated 4.9 / 5 from over 2,000 reviews
“Mina is extremely thorough, never ever overdone and never tells you to do more than you need or want. Really really good at her job.”
Polynucleotides are purified molecules associated with skin repair and renewal. Injected into the skin, they support your own regeneration rather than adding anything to your face.
This is not a cream and it is not a facelift. Polynucleotides work by supporting the skin's natural repair and regeneration processes from within. Once placed, they help improve hydration, calm inflammation and stimulate collagen production. Over a course, the skin becomes stronger, smoother and more resilient, with a healthier overall appearance.
That distinction matters when you are choosing between treatments. Polynucleotides are a skin quality treatment, not a volume treatment. They will not change the shape of your face, sharpen a jawline or lift a cheek. What they do is improve the fabric of the skin itself: hydration, texture, elasticity, tone and how well it copes with irritation.
It is a popular choice for people with tired, dull or fragile skin, for the delicate under-eye area, and for anyone who wants visible rejuvenation while keeping the result soft, natural and in balance with the rest of the face. At Dermamina, the plan is built around your skin at your consultation rather than sold as a fixed package.
Both are injectables. They are trying to do completely different things.
| Aspect | Polynucleotides | Dermal filler |
|---|---|---|
| What it does | Supports repair and regeneration to improve the quality of the skin itself. | Adds volume beneath the skin to change shape, contour or projection. |
| Visible effect | Healthier, more hydrated, more resilient skin with softer fine lines. | A structural change: fuller lips, a defined jaw, restored cheek volume. |
| Risk of an overdone look | None. Nothing is being added to your features. | Real, if overdone or placed poorly. |
| Best for | Dull, tired, fragile or sensitised skin, under-eyes, fine lines and acne scarring. | Volume loss, contour and structural change. |
| Sessions | A course of 3, spaced 3 to 4 weeks apart, with results building gradually. | Usually a single appointment, with results visible immediately. |
| How long it lasts | 6 to 12 months, with maintenance sessions to sustain skin quality. | Typically 12 to 18 months depending on the product and area. |
Most people who book this treatment are not trying to look different. They are trying to look less tired. Polynucleotides improve skin quality without changing your features: deeper hydration, better texture, more elasticity, and skin that is genuinely more resilient rather than just temporarily plumped.
That makes it one of the gentler options we offer, and one of the most useful in areas where filler is a blunt instrument. The under-eye is the clearest example: delicate skin that shows every bit of fatigue, where the goal is stronger, better-hydrated skin rather than added volume. Results build gradually over a course and keep improving as collagen rebuilds.
Book nowWe assess your skin, discuss your goals and confirm whether polynucleotides are genuinely the right treatment. You get honest advice, clear pricing and no pressure to proceed.
Numbing cream can be applied beforehand for comfort. We confirm the areas to be treated and the depth for your skin on the day.
A fine needle places the polynucleotides into the skin across carefully selected points, matched to your skin's condition and the area being treated. Most appointments take 10 to 20 minutes.
Most people return to normal activities straight away. For the first 24 hours avoid touching the area unnecessarily, heavy exercise, heat exposure and makeup. Mild redness, swelling or small injection marks can happen and generally settle quickly.
Polynucleotides suit adults of any age who want to improve the health and appearance of their skin without changing their features. They can be used on the face, neck, décolletage, around the eyes and on the hands.
It is not right for everyone. If you are pregnant or breastfeeding, have an active skin infection in the area, or a known allergy to any component, we will suggest an alternative. Tell your practitioner about any allergies or medical conditions before treatment.
Courses of six are 10% off the single-session price. Final pricing is confirmed at your free consultation, with no obligation to proceed.
Every treatment is carried out in our Save Face accredited clinic on New Cavendish Street, five minutes from Oxford Street, by a medically qualified team.
The face, neck, décolletage, the area around the eyes, and the hands.
Most patients benefit from a course of 3 to 4 treatments spaced 3 to 4 weeks apart. The exact number depends on your skin and your goals.
Discomfort is minimal. A topical anaesthetic can be applied beforehand to keep you comfortable.
Initial results appear within a few weeks, with continued improvement over several months as collagen production increases.
At Dermamina, polynucleotides start at £300 for one area. Two areas are £450, three areas £600 and four areas £700. A course of six is discounted by 10%, bringing one area to £270 per session. Your skin consultation is free.
Minimal. Some people have mild redness or swelling which settles within a day or two.
Yes. They combine well with microneedling and exosomes, and with hyaluronic acid where hydration is the priority. Combination pricing is listed above.
Side effects are minimal and may include temporary redness, swelling or bruising at the injection site. These usually resolve quickly.
Typically around 6 to 12 months. A maintenance session every 6 to 12 months helps sustain skin quality.
Skin texture, fine lines and wrinkles, hydration, redness, acne scarring, and overall skin quality and radiance.
Yes. They stimulate collagen production and can improve the appearance of acne scarring over a course of treatments.
No. Polynucleotides are suitable for adults of all ages who want to improve the health and appearance of their skin.
Wait at least 24 hours before applying makeup, so the skin can heal fully.
Avoid harsh skincare products in the days before your appointment, stay well hydrated, avoid smoking, and tell your practitioner about any allergies or medical conditions.
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